Vol. 4, Issue 2, Part A (2022)

One of the greatest public health issues is cancer, which is the second major cause of death for mortality in the globe. The rate of prevalence and fatality of cancer continue to be high despite significant advancements in cancer therapy. Therefore, the hunt for more effective and benign cancer treatment methods is at the forefront of scientific inquiry. The primary component of the Curcuma longa plant, curcumin, has drawn a lot of interest as an antioxidant, anti-inflammatory, and anticancer agent over the past 20 years. Based on literature data from experimental and clinical evaluations of curcumin in cancer cell lines based on animal models, and human subjects, in regards to their anticancer activities, primary modes of action, and cellular targets, this review article examines the medicinal chemistry and medicinal chemistry of curcumin and its derivatives. The discipline of pharmacology was described. In addition, current developments in curcumin delivery systems for cancer cells were emphasized.